A model β-sheet interaction and thermodynamic analysis of β-strand mimetics.
نویسندگان
چکیده
β-Sheet mediated protein-protein interactions are involved in key signalling pathways in diseases such as cancer. We present small molecule β-strand mimetics and investigate their interactions with a model tripeptide. Using (1)H NMR, the thermodynamic parameters for their binding are determined. These give insight into this biologically important interaction.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 27 شماره
صفحات -
تاریخ انتشار 2015